Male and female relatives of young women with breast cancer are at greater risk of developing cancer themselves, according to research published today.
Scientists studied parents and siblings of 504 women diagnosed with the disease before the age of 35 and found they were at a 1.5 to two-fold increased risk of prostate, lung, brain and urinary cancers.
The risk was little changed among the relatives of women who did not carry known faulty genes that increase the chance of breast cancer. That suggested there may be other undiscovered gene disorders causing cancer in young women and their families, the researchers said, meaning further work could help identify more people who might be susceptible.
Women who inherit one of the abnormal genes known as BRCA1 and BRCA2 have a 55% to 85% risk of developing breast cancer in their lifetime. But most women with the disease do not have the high-risk genes, which only account for between 2% and 5% of all breast cancers.
Professor John Hopper, from the Centre for Molecular, Environmental, Genetic and Analytic Epidemiology at the University of Melbourne, who led the study published in the British Journal of Cancer (BJC), said: "These results are surprising and novel, and could be pointing to a new cancer genetic syndrome.
"Just as the link between male and female breast cancers in some families led UK researchers to find the breast cancer susceptibility gene BRCA2, the results of this study could help scientists discover new cancer susceptibility genes." Dr Lesley Walker, the director of cancer information at Cancer Research UK, which owns the BJC, said: "These early results are interesting in pointing to some increased risks of other cancers in the relatives of very young breast cancer cases. This study is important in suggesting a strategy to help identify other genes which significantly increase a woman's breast cancer risk. More studies with larger numbers will help confirm these risks."
It is already known that relatives of early onset breast cancer patients without mutations in BRCA1 and BRCA2 carry up to a four-fold increased risk of the disease compared with those with no family link, but this study suggests close relatives also face higher chances of other cancers.
It also backed up earlier research by finding that mothers and sisters of women with breast cancer had a substantially increased risk of the disease, even if the women did not have a BRCA mutation. The risk for sisters was greater than for mothers. Previous studies have suggested increased risks of other cancers for relatives of women with breast cancer, but the links have been weak and inconsistent.
Of the 504 women in the study, 41 had a BRCA mutation. A total of 2,200 parents and siblings were involved.
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